Brain alterations and neurocognitive dysfunction in patients with complex regional pain syndrome
Do-Hyeong Lee, MD, Kyung-Jun Lee, MD, Kang Ik K. Cho, Eun Chung Noh, MA, Joon Hwan Jang, MD, PhD, Yong Chul Kim, MD, PhD, Do-Hyung Kang, MD, PhD
Received: September 29, 2014; Received in revised form: February 7, 2015; Accepted: March 14, 2015; Published Online: March 31, 2015
Highlights
- •Significant cortical thinning in the prefrontal cortex was observed in CRPS patients.
- •Patients with CRPS made significantly more perseverative errors on the WCST.
- •Patients with CRPS showed significantly longer stop-signal response time.
- •The alterations may explain executive dysfunction and disinhibited pain perception.
“The present study reports decreased cortical thickness in the prefrontal cortex and neurocognitive dysfunctions in patients with complex regional pain syndrome. These findings may contribute to the understanding of pain-related impairments in cognitive function and could help explain the symptoms or progression of complex regional pain syndrome.”
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